Dear Reader: This editorial 444 – the number calls for attention – is dedicated to a global overview, the world “right now”, so unstable with imbalances everywhere that what we are living is fluxes and jumps. Let us start with two major relations: Nature-human, the US-the Rest. Look at the human-nature relations. We are used to being on top, killing and taming animals, protected against many of nature’s hazards including micro-organisms. But nature comes up with ever smaller viri, and larger, or more, tsunamis and earthquakes, and an erratic climate. We oscillate between blaming ourselves, including military scheming, and the anthropomorphic “Mother Nature is angry” (Evo Morales). If nature is angry, she has good reasons for a good riddance of us. And we are slow at a deeper human-nature relations respecting and enhancing both. Nature is on top and our natural sciences are simply not good enough, taken by surprise...